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KMID : 0380020070220040213
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Korean Journal of Biotechnology and Bioengineering
2007 Volume.22 No. 4 p.213 ~ p.217
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Effects of Hydrophilic Additives on the Release Rate of Protein Drugs
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Kwon Young-Kuan
Kim Jee-Hyun
Yoo Young-Je
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Abstract
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It has been reported that hydrophobic additives generally decrease the release rate of protein drugs from drug delivery systems (DDS) and hydrophilic additives increase the release rate. In many cases, however, the addition of hydrophilic molecule is necessary for improving the stability of protein drugs. In the present work, the effects of hydrophilic additives on the release profiles, and micelle formation of protein drug formulations were investigated to develop a novel method for protein drug delivery. For model protein drug, bovine serum albumin (BSA) was employed and several hydrophilic additives were used in the release experiments. Hydrophilic additive D-sorbitol showed the lower release rates of BSA than other hydrophobic additives due to the gel strengthening ability of the additive and the optimum concentration of D-sorbitol was 3 w/v % for the retarded release rate. In addition, it was found that the addition of D-sorbitol was very effective for obtaining homogeneous and stable DDS. The results were discussed in terms of the micelle formation and the micelle structure, i.e., the differences in gel structure and the distribution of drugs in micelles.
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KEYWORD
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Protein drug formulation, drug delivery, pluronics, additive, D-sorbitol
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